(11/01/2006 - 16:52)
Roberta Jansen
O mesmo princípio do Viagra, a pílula contra a impotência masculina, está sendo pesquisado no mundo todo para o desenvolvimento de drogas contra os mais diversos males, do Alzheimer à incontinência urinária.
Pelo menos 15 novos medicamentos baseados no papel desempenhado pelo gás óxido nítrico no organismo humano já estão em fase de teste clínico e devem chegar ao mercado dentro de, no máximo, cinco anos, conforme foi revelado ontem no Simpósio Internacional sobre Óxido Nítrico, organizado pela Fiocruz, no Rio.
- Dois tipos de drogas estão sendo desenvolvidos: as doadoras de óxido nítrico e as que estimulam a produção de óxido nítrico no corpo - revelou o cientista americano Louis Ignarro, ganhador do prêmio Nobel de Medicina de 1998 por suas descobertas relacionadas à ação do óxido nítrico no organismo.
- Estão sendo testados medicamentos contra mal de Alzheimer, úlcera, hipertensão, incontinência urinária, entre outros.
Produzido em diversos tecidos do corpo, o óxido nítrico teria funções múltiplas, segundo Ignarro.
A principal delas seria a vasodilatadora, que estimula o fluxo sangüíneo e, por isso, seria importante na prevenção de hipertensão, derrames e arteriosclerose.
- Sabemos hoje que os pacientes com mal de Alzheimer apresentam deficiência de óxido nítrico em algumas partes do cérebro - explicou.
Segundo Ignarro, o óxido tem uma função protetora do organismo: suas características antioxidantes preveniriam inflamações.
Alguns estudos já sugerem que o óxido seria importante também na prevenção do câncer.
O Globo
segunda-feira, 16 de março de 2009
sábado, 14 de março de 2009
Nitric Oxide Can Alter Brain Function
Science News Share Blog Cite Print Email BookmarkNitric Oxide Can Alter Brain Function
ScienceDaily (Nov. 27, 2008) — Research from the Medical Research Council (MRC) Toxicology Unit at the University of Leicester shows that nitric oxide (NO) can change the computational ability of the brain. This finding has implications for the treatment of neurodegenerative diseases such as Alzheimer's Disease and our understanding of brain function more generally.
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The research is led by Professor Ian Forsythe and is reported in the journal Neuron on 26th November.
Professor Forsythe, of the MRC Toxicology Unit, explains: "It is well known that nerve cells communicate via the synapse – the site at which chemical messengers (neurotransmitters such as acetylcholine or glutamate) are packaged and then released under tight control to influence their neighbours.
"Nitric oxide is a chemical messenger which cannot be stored and can rapidly diffuse across cell membranes to act at remote sites (in contrast to conventional neurotransmitters which cannot pass across cell membranes).
"It is broadly localized in the central nervous system, where it influences synaptic transmission and contributes to learning and memory mechanisms. However, because it is normally released in such minute quantities and is so labile, it is very difficult to study.
"We have exploited an in vitro preparation of a giant synapse -called the calyx of Held, developed here at the University of Leicester in the 1990s- and its target in the auditory pathway to explore nitric oxide signalling in the brain.
"We show that NO is made in response to incoming synaptic activity (activity generated by sound received by the ear) and that it acts to suppress a key potassium ion-channel (Kv3). Normally these ion-channels keep electrical potentials very short-lived, but nitric oxide shifts their activity, slowing the electrical potentials and reducing information passage along the pathway, acting as a form of gain control.
"Surprisingly, the whole population of neurons were affected, even those neurons which had no active synaptic inputs, so indicating that nitric oxide is a 'volume transmitter' passing information between cells without the need for a synapse. Such a function is ideal for tuning neuronal populations to global activity. On the other hand, too much nitric oxide is extremely toxic and will cause death of nerve cells; so within the kernel of this important signaling mechanism are the potential seeds for neurodegeneration, which if left unchecked contribute to the pathologies of stroke and dementias."
In the future Professor Forsythe's research group will be trying to understand how these signalling mechanisms are applicable elsewhere in the brain and will investigate how aberrant signalling contributes to neurodegenerative disease processes such as in Alzheimer's disease.
--------------------------------------------------------------------------------
Adapted from materials provided by University of Leicester, via EurekAlert!, a service of AAAS.
Email or share this story:
ScienceDaily (Nov. 27, 2008) — Research from the Medical Research Council (MRC) Toxicology Unit at the University of Leicester shows that nitric oxide (NO) can change the computational ability of the brain. This finding has implications for the treatment of neurodegenerative diseases such as Alzheimer's Disease and our understanding of brain function more generally.
--------------------------------------------------------------------------------
The research is led by Professor Ian Forsythe and is reported in the journal Neuron on 26th November.
Professor Forsythe, of the MRC Toxicology Unit, explains: "It is well known that nerve cells communicate via the synapse – the site at which chemical messengers (neurotransmitters such as acetylcholine or glutamate) are packaged and then released under tight control to influence their neighbours.
"Nitric oxide is a chemical messenger which cannot be stored and can rapidly diffuse across cell membranes to act at remote sites (in contrast to conventional neurotransmitters which cannot pass across cell membranes).
"It is broadly localized in the central nervous system, where it influences synaptic transmission and contributes to learning and memory mechanisms. However, because it is normally released in such minute quantities and is so labile, it is very difficult to study.
"We have exploited an in vitro preparation of a giant synapse -called the calyx of Held, developed here at the University of Leicester in the 1990s- and its target in the auditory pathway to explore nitric oxide signalling in the brain.
"We show that NO is made in response to incoming synaptic activity (activity generated by sound received by the ear) and that it acts to suppress a key potassium ion-channel (Kv3). Normally these ion-channels keep electrical potentials very short-lived, but nitric oxide shifts their activity, slowing the electrical potentials and reducing information passage along the pathway, acting as a form of gain control.
"Surprisingly, the whole population of neurons were affected, even those neurons which had no active synaptic inputs, so indicating that nitric oxide is a 'volume transmitter' passing information between cells without the need for a synapse. Such a function is ideal for tuning neuronal populations to global activity. On the other hand, too much nitric oxide is extremely toxic and will cause death of nerve cells; so within the kernel of this important signaling mechanism are the potential seeds for neurodegeneration, which if left unchecked contribute to the pathologies of stroke and dementias."
In the future Professor Forsythe's research group will be trying to understand how these signalling mechanisms are applicable elsewhere in the brain and will investigate how aberrant signalling contributes to neurodegenerative disease processes such as in Alzheimer's disease.
--------------------------------------------------------------------------------
Adapted from materials provided by University of Leicester, via EurekAlert!, a service of AAAS.
Email or share this story:
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